Anti-ELF1抗体E74 ike Factor 1 is a transcription factor that may be required for the T-cell receptor mediated activation of HIV2 gene expression.

产品编号 yb-7042R
英文名称 Anti-ELF1抗体
中文名称 转录因子ELF1抗体
别    名 mElf 1; E74 like factor 1; ELF 1; ELF1; Ets domain transcription factor; ETS related transcription factor Elf 1; ETS related transcription factor Elf1; p70; Sts1; TRANSCRIPTION FACTOR ELF 1; ELF1_HUMAN.
Anti-ELF1抗体  
说 明 书 0.2ml  
研究领域 细胞生物  染色质和核信号  信号转导  转录调节因子  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, rt
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 67kDa
细胞定位 细胞核 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human ELF1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
E74 ike Factor 1 is a transcription factor that may be required for the T-cell receptor mediated activation of HIV2 gene expression. It binds to two purine-rich motifs in the HIV-2 enhancer and transcriptionally activates the LYN and mouse BLK promoters.

Function:
Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer.

Subunit:
Binds to the underphosphorylated form of RB. May interact with other transcription factors in order to regulate specific genes. Interacts with RUNX1. 

Subcellular Location:
Nucleus.

Tissue Specificity:
In fetal tissues, it is highly expressed in heart, lung liver and kidney, and weakly expressed in brain. In adult, it is highly expressed in pancreas, spleen, thymus and peripheral blood leukocytes, expressed at moderate levels in heart, placenta, lung, liver, skeletal muscle, kidney, prostate, ovary, small intestine and colon, and weakly expressed in brain and testis.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Belongs to the ETS family.
Contains 1 ETS DNA-binding domain.