Anti-CDCREL抗体家族是细胞骨架蛋白的一种，具有GTPase的活性。经研究发現，SEPT参与细胞的分裂、细胞膜的运输以及构成细胞骨架。SEPTIN5又称细胞骨架蛋白SEPT5。

产品编号 yb-6905R
英文名称 Anti-CDCREL抗体
中文名称 细胞周期调控相关蛋白1
别    名 5 Sep; CDCrel 1; CDCREL; CDCrel-1; CDCREL1; Cell division control related protein 1; Cell division control-related protein 1; H5 antibody HCDCREL 1; Peanut like 1; Peanut like 1 homolog; Peanut like protein 1; Peanut-like protein 1; Plaet glycoprotein Ib beta chain; PNUTL1; SEPT5; SEPT-5; SEPT 5; SEPT5_HUMAN; Septin 5; Septin5; Septin-5.
Anti-CDCREL抗体   
说 明 书 0.2ml  
研究领域 细胞生物  免疫学  细胞周期蛋白  细胞分化  细胞骨架  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 41kDa
细胞定位 细胞浆 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CDCREL/SEPT5
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; plaet glycoprotein Ib), whereby larger, non-coding transcripts are produced. [provided by RefSeq, Dec 2010].

Function:
Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in plaet secretion.

Subunit:
Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Interacts with SEPT2 and SEPT5. In plaets, associated with a complex containing STX4. Interacts with PARK2. This interaction leads to SEPT5 ubiquitination and degradation.

Subcellular Location:
Cytoplasm. Cytoplasm, cytoskeleton. Note=In plaets, found in areas surrounding alpha-granules

Tissue Specificity:
Expressed at high levels in the CNS, as well s in heart and plaets (at protein level).

Post-translational modifications:
In plaets, phosphorylated in response to thrombin, phorbol-12-myristate-13-acetate and collagen.

Similarity:
Belongs to the septin family.

Database links:
UniProtKB/Swiss-Prot: Q99719.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

家族是细胞骨架蛋白的一种，具有GTPase的活性。经研究发現，SEPT参与细胞的分裂、细胞膜的运输以及构成细胞骨架。SEPTIN5又称细胞骨架蛋白SEPT5。