Anti-CRIPTO抗体是表皮生长因子-Cripto-FRL-Criptic（EGF-CFC）家族成员之一, 属于转化生长细胞TGF-β蛋白家族及Nodal蛋白质的共同受体

产品编号 yb-2313M
英文名称 Anti-CRIPTO抗体
中文名称 畸胎瘤衍化生长因子单克隆抗体
别    名 CRIPTO; CRIPT; CR; CRGF; Cripto 1; Cripto-1; Cripto 1 growth factor; Cripto-1 growth factor; Cripto1; Cripto1 growth factor; Epidermal growth factor like cripto protein CR1; Epidermal growth factor-like cripto protein CR1; TDGF 1; TDGF-1; TDGF1; Teratocarcinoma derived growth factor 1; Teratocarcinoma-derived growth factor 1; teratocarcinoma-derived growth factor 1 isoform 1 precursor; TDGF1_HUMAN.
Anti-CRIPTO抗体
说 明 书 0.1ml  0.2ml  
研究领域 肿瘤  免疫学  生长因子和激素  
抗体来源 Mouse
克隆类型 Monoclonal
克 隆 号 1F10
交叉反应 Human, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 13kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Teratocarcinoma-derived growth factor 1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010].

Function:
Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.

Subunit:
Interacts with the activin type-1 receptor ACVR1B.

Subcellular Location:
Cell membrane; Lipid-anchor, GPI-anchor.

Tissue Specificity:
Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung.

Similarity:
Contains 1 EGF-like domain.

是表皮生长因子-Cripto-FRL-Criptic(EGF-CFC)家族成员之一, 属于转化生长细胞TGF-β蛋白家族及Nodal蛋白质的共同受体。Cripto蛋白对于胚胎的发育占有非常重要的地位。 Cripto-1在人类的多种肿瘤如结肠癌、乳腺癌、卵巢癌、胰腺癌等中高表达，可激活P13K/Akt/GSK-3βc-Src和ras/raf/MAPK信号通路,介导细胞增殖和抑制细胞凋亡，Cripto蛋白的单细胞繁殖抗体，可以有效抑制一些癌细胞的生长。