Anti-CREM抗体是一种与CREB高度同源的蛋白，与CREB均一表达于几种细胞类型不同，其表达具有细胞特异性,CREM同CREB一样能高效特异性结合到CRE元件上，但相反的是其下调cAMP诱导的转录.

产品编号 yb-5135R
英文名称 Anti-CREM抗体
中文名称 *反应元件调节蛋白抗体
别    名 cAMP response element modulator; CREM-1; cAMP responsive element modulator; hCREM 2; hCREM2; ICER; Inducible cAMP early repressor; Inducible cAMP early repressor ICER; MGC111110; MGC17881; MGC41893.
Anti-CREM抗体  
说 明 书 0.1ml  0.2ml  
研究领域 肿瘤  免疫学  转录调节因子  激酶和磷酸酶  结合蛋白  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Pig, Horse, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 40kDa
细胞定位 细胞核 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CREM
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
CREM is a a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is derived from a multiexonic gene that encodes both activators and antagonists of cAMP-inducible transcription by differential splicing. Splice variants with antagonistic function lack 2 glutamine-rich domains and block cAMP-induced transcription, whereas an isoform that includes these glutamine-rich domains is a transcriptional activator.

Function:
Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (By similarity).

Subunit:
Binds DNA as a dimer. Interacts with FHL5. Interacts with CDC34.

Subcellular Location:
Nucleus.

Tissue Specificity:
Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes.

Post-translational modifications:
Isoform 9 is ubiquitinated by CDC34 and RAD6B in order to be degraded by the proteasome. 
Stimulated by phosphorylation.

Similarity:
Belongs to the bZIP family. 
Contains 1 bZIP domain.
Contains 1 KID (kinase-inducible) domain.

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

是一种与CREB高度同源的蛋白，与CREB均一表达于几种细胞类型不同，其表达具有细胞特异性,CREM同CREB一样能高效特异性结合到CRE元件上，但相反的是其下调cAMP诱导的转录.