Anti-CAPZA2抗体The protein encoded by this gene is a member of the F-actin capping protein alpha subunit family. It is the alpha subunit of the barbed-end actin binding protein Cap Z.

产品编号 yb-5128R
英文名称Anti-CAPZA2抗体
中文名称 F肌动蛋白α2亚基抗体
别    名 CAPPA2; CapZ alpha 2; Capping protein (actin filament) muscle Z line, alpha 2; CapZ alpha 2; CAPZ; F actin capping protein subunit alpha 2; CAZA2_HUMAN.
Anti-CAPZA2抗体    
说 明 书 0.1ml  0.2ml  
研究领域 细胞生物  免疫学  信号转导  转录调节因子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 33kDa
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CapZ alpha 2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
The protein encoded by this gene is a member of the F-actin capping protein alpha subunit family. It is the alpha subunit of the barbed-end actin binding protein Cap Z. By capping the barbed end of actin filaments, Cap Z regulates the growth of the actin filaments at the barbed end. [provided by RefSeq, Jul 2008]

Function:
F-actin-capping proteins bind in a Ca(2+)-independentmanner to the fast growing ends of actin filaments (barbed end)thereby blocking the exchange of subunits at these ends. Unlikeother capping proteins (such as gelsolin and severin), theseproteins do not sever actin filaments.

Subunit:
Heterodimer of an alpha and a beta subunit. Component ofthe WASH complex, composed of F-actin-capping protein subunit alpha(CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta(CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P),FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 and CCDC53.Interacts with RCSD1/CAPZIP.

Similarity:
Belongs to the F-actin-capping protein alpha subunitfamily.


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.