Anti-CDC34B抗体UBC3B is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation.

产品编号 yb-3813R
英文名称Anti-CDC34B抗体
中文名称 泛素载体蛋白R2抗体
别    名 CDC34B; E2 CDC34B; UBE2R2; Ubiquitin carrier protein R2; Ubiquitin conjugating enzyme E2 CDC34B; Ubiquitin conjugating enzyme E2 R2; Ubiquitin conjugating enzyme E2R 2; Ubiquitin conjugating enzyme UBC3B; Ubiquitin protein ligase R2.
Anti-CDC34B抗体   
说 明 书 0.2ml  
研究领域 细胞生物  免疫学  信号转导  转录调节因子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Horse, Rabbit, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 26kDa
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CDC34B(128-165aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
UBC3B is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation.

Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes monoubiquitination and 'Lys-48'-linked polyubiquitination. May be involved in degradation of katenin.

Subunit:
When phosphorylated, interacts with beta-TrCP (BTRC).

Similarity:
Belongs to the ubiquitin-conjugating enzyme family.


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.