Anti-ABI2抗体ABI2 （Abelson interactor 2） belongs to the ABI family. The Abelson interactors are among a group of proteins that interact with Abl tyrosine kinase,

产品编号 yb-5984R
英文名称 Anti-ABI2抗体
中文名称 肿瘤抑制基因ABI2/**蛋白激酶结合蛋白抗体
别    名 Abelson interactor 2; ABI 2; ABI2B; Abl binding protein 3; Abl interacting protein 1 (SH3 containing protein); Abl interactor 2; Abl interactor protein 2b; AblBP3; AIP 1; Arg binding protein 1; Arg protein tyrosine kinase binding protein; ArgBP1; ARGBPIA; ArgBPIB; SSH3BP2; ABI2_HUMAN.
Anti-ABI2抗体  
说 明 书 0.1ml  0.2ml  
研究领域 肿瘤  免疫学  激酶和磷酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Rabbit, Sheep, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 56kDa
细胞定位 细胞浆 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human ABI2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
ABI2 (Abelson interactor 2) belongs to the ABI family. The Abelson interactors are among a group of proteins that interact with Abl tyrosine kinase, a non-receptor tyrosine kinase whose activation results in the regulation of cytoskeleton function, cell growth and apoptosis in response to a variety of biological stimuli. 

Function:
May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA. [SUBUNIT] Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the complex, a heterdimer containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by WAVE1, ABI2 and BRK1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1 (By similarity). Interacts with ABL1 and ABL2. 

Subcellular Location:
Cytoplasm (By similarity). 
Isoform 1: Cell projection, lamellipodium (By similarity). Cell projection, filopodium (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Isoform 1 but not isoform 3 is localized to protruding lamellipodia and filopodia tips (By similarity). 

Post-translational modifications:
Is a substrate for ABL1. 

Similarity:
Belongs to the ABI family. 
Contains 1 SH3 domain. 
Contains 1 t-SNARE coiled-coil homology domain. 

Database links:
UniProtKB/Swiss-Prot: Q9NYB9.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.