Anti-ADCY9抗体蛋白激酶AKT-2，被认为也是原癌基因之一。受PDGF，EGF，FGF激活，经过phosphatidylinositol 3-kinase作用而活化。通过对凋亡调控蛋白的磷酸化而灭活其活性，抑制细胞的凋亡.

产品编号 yb-3926R
英文名称 Anti-ADCY9抗体
中文名称 腺苷酸环化酶9抗体
别    名 ADCY 9; Adenylate cyclase 9; Adenylate cyclase type 9; Adenylate cyclase type IX; Adenylyl cyclase 9; ATP pyrophosphate lyase 9; KIAA0520; Type IX adenylyl cyclase; Type IX ATP pyrophosphate lyase; ADCY9_HUMAN.
Anti-ADCY9抗体  
说 明 书 0.2ml  
研究领域 肿瘤  免疫学  信号转导  细胞凋亡  生长因子和激素  转录调节因子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 150kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human ADCY9
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. It is regulated by a family of G protein-coupled receptors, protein kinases, and calcium. The type 9 adenylyl cyclase is a widely distributed adenylyl cyclase, and it is stimulated by beta-adrenergic receptor activation but is insensitive to forskolin, calcium, and somatostatin. [provided by RefSeq, Jul 2008].

Function:
May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity).

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Expressed in multiple cells of the lung, with expression highest in airway smooth muscle.

Similarity:
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Contains 2 guanylate cyclase domains.

Database links:
UniProtKB/Swiss-Prot: O60503.4

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.