Anti-ADCY8抗体一种调节细胞内*流出的膜蛋白，其功能障碍将导致巨噬细胞内沉积大量的*而成为泡沫细胞，继而浸润血管壁，促进动脉粥样硬化的发生、发展。

产品编号 yb-3925R
英文名称 Anti-ADCY8抗体
中文名称 腺苷酸环化酶8抗体
别    名 ADCY 8; Adenylate cyclase 8; Adenylate cyclase type VIII; Adenylyl cyclase 8 brain; ATP pyrophosphate-lyase 8; Brain adenylate cyclase 8; Ca(2+)/calmodulin activated adenylyl cyclase; EC 4.6.1.1; HBAC1; ADCY8_HUMAN.
Anti-ADCY8抗体
说 明 书 0.2ml  
研究领域 肿瘤  细胞生物  免疫学  信号转导  生长因子和激素  转录调节因子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 140kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human ADCY8
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase [provided by RefSeq, Jul 2008].

Function:
This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity).

Subcellular Location:
Membrane; Multi-pass membrane protein.

Similarity:
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Contains 2 guanylate cyclase domains.

Database links:
UniProtKB/Swiss-Prot: P40145.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.