Anti-ADCY2抗体β抑制因子-2又称β休止蛋白2，也是是调节CD4+T细胞存活和自身免疫性的关键因子，与促进T淋巴细胞存活和自身免疫发病相关。经研究发现β-arrestin不仅仅能阻断蛋白合成，也能诱导蛋白合成，参与信号传导。

产品编号 yb-3920R
英文名称 Anti-ADCY2抗体
中文名称 腺苷酸环化酶2抗体
别    名 adenylate cyclase 2; HBAC2; KIAA1060; type II adenylate cyclase; ADCY2_HUMAN.
 Anti-ADCY2抗体  
说 明 书 0.2ml  
研究领域 肿瘤  细胞生物  免疫学  信号转导  生长因子和激素  转录调节因子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 124kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human ADCY2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
 
PubMed PubMed
产品介绍 background:
ADCY2 is a membrane-bound, calmodulin-insensitive adenylyl cyclase.

Function:
This is a membrane-bound, calmodulin-insensitive adenylyl cyclase. 

Subunit:
Interacts with RAF1. 

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Expressed in brain.

Post-translational modifications:
Phosphorylated by RAF1.

Similarity:
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. 
Contains 2 guanylate cyclase domains.

Database links:
UniProtKB/Swiss-Prot: Q08462.5

 Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.