Anti-Amphiregulin抗体β-淀粉样蛋白来自β-淀粉样蛋白原，在脑组织的细胞外呈丝状蛋白样沉积 ，是淀粉样结节性神经炎病变的主要蛋白成分，在神经纤维中也有沉积。

产品编号 yb-3847R
英文名称 Anti-Amphiregulin抗体
中文名称 双调蛋白/结肠直肠细胞源性生长因子抗体
别    名 AR; Colorectum cell derived growth factor; CRDGF; A REG; AR antibody; AREG; Colorectum cell derived growth factor; CRDGF; MGC13647; Schwannoma derived growth factor; SDGF; AREG_HUMAN.
Anti-Amphiregulin抗体 
说 明 书 0.1ml  0.2ml  
研究领域 肿瘤  细胞生物  免疫学  神经生物学  生长因子和激素  转录调节因子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 16kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Amphiregulin C-terminus
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
Amphiregulin expression is induced by phorbol ester, estrogen, androgen, and other EGFR ligands. In vitro, amphiregulin functions as an autocrine growth stimulator to drive proliferation of colon carcinoma cells, normal and oncogene-transformed mammary epithelial cells, cervical carcinoma cells, prostate cancer cells, and keratinocytes. Amphiregulin is important in the development of human placenta and murine mammary gland. It is reportedly overexpressed in human cancers of breast, colon, stomach and pancreas.

Function:
Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.

Subunit:
The immature precursor interacts with CNIH.

Subcellular Location:
Membrane; Single-pass membrane protein.

Similarity:
Belongs to the amphiregulin family. 
Contains 1 EGF-like domain.


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.