Anti-EXOC1抗体Exocytosis is crucial in membrane trafficking and it mediates hormone and neurotransmitter secretion out of the cell,

产品编号 yb-14657R
英文名称 Anti-EXOC1抗体
中文名称 EXOC1蛋白抗体
别    名 BM-012; exoc1; EXOC1_HUMAN; Exocyst complex component 1; Exocyst complex component Sec3; FLJ10893; SEC3; SEC3 like 1; SEC3L1; SEC3P.
Anti-EXOC1抗体   
说 明 书 0.2ml  
研究领域 细胞生物  转运蛋白  细胞骨架  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Horse, Sheep, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 102kDa
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human EXOC1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4
PubMed PubMed
产品介绍 background:
Exocytosis is crucial in membrane trafficking and it mediates hormone and neurotransmitter secretion out of the cell, as well as the incorporation of membrane proteins and lipids to the plasma membrane. It is crucial for cell-cell communication, cell growth and cell polarity. The exocyst complex is a multi-protein complex that consists of Sec3, Sec5, Sec6, Sec8, Sec10, Sec15, Exo70 and Exo84, and is essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Exo70, also known as EXOC7 (exocyst complex component 7), EXOC1 or 2-5-3p, is a 735 amino acid peripheral membrane protein that is a component of the exocyst complex. Localized to the cytoplasm and the cell membrane, Exo70 plays an essential role in the docking of exocystic vesicles to target sites on the plasma membrane and, specifically, may be involved in insulin-induced protein docking within the cell. Four isoforms of Exo70 are expressed due to alternative splicing events.

Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Subunit:
The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8.

Similarity:
Belongs to the SEC3 family.