Anti-EESSPL抗体ESPNL is a 1,005 amino acid protein that contains nine ANK repeats and exists as three alternatively spliced isoforms.

产品编号 yb-14638R
英文名称 Anti-EESSPL抗体
中文名称 ESSPL蛋白抗体
别    名 Epidermis specific serine protease like protein; Epidermis-specific serine protease-like protein; Gm1019; Protease serine 48; PRS48_HUMAN; PRSS48; Serine protease 48.
 Anti-EESSPL抗体
说 明 书 0.2ml  
研究领域 细胞生物  信号转导  泛素  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 34kDa
细胞定位 细胞浆 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human ESSPL
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4  
PubMed PubMed
产品介绍 background:
ESPNL is a 1,005 amino acid protein that contains nine ANK repeats and exists as three alternatively spliced isoforms. The gene encoding ESPNL maps to human chromosome 2q37.3 and mouse chromosome 1 D. Chromosome 2 is the second largest human chromosome, which consists of 237 million bases, encodes over 1,400 genes and makes up approximay 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8. An extremely rare recessive genetic disorder known as Alstrom syndrome is due to mutations in the ALMS1 gene. Interestingly, chromosome 2 contains what appears to be a vestigial second centromere and vestigial omeres which gives credence to the hypothesis that human chromosome 2 is the result of an ancient fusion of two ancestral chromosomes seen in modern form today in apes.

Subcellular Location:
Secreted.
 
Similarity:
Belongs to the peptidase S1 family.
Contains 1 peptidase S1 domain.