Anti-EEML1抗体Human echinoderm microtubule-associated protein-like is a strong candidate for the Usher syndrome type 1A gene.

产品编号 yb-14586R
英文名称 Anti-EEML1抗体
中文名称 EML1蛋白抗体
别    名 echinoderm microtubule associated protein like 1; Echinoderm microtubule-associated protein-like 1; ELP79; EMAL1_HUMAN; EMAP; EMAP-1; EMAPL; Eml1; FLJ45033; HuEMAP; HuEMAP-1.
Anti-EEML1抗体 
说 明 书 0.1ml  0.2ml  
研究领域 细胞生物  发育生物学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 90kDa
细胞定位 细胞浆 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human EML1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
Human echinoderm microtubule-associated protein-like is a strong candidate for the Usher syndrome type 1A gene. Usher syndromes (USHs) are a group of genetic disorders consisting of congenital deafness, retinitis pigmentosa, and vestibular dysfunction of variable onset and severity depending on the genetic type. The disease process in USHs involves the entire brain and is not limited to the posterior fossa or auditory and visual systems. The USHs are catagorized as type I (USH1A, USH1B, USH1C, USH1D, USH1E and USH1F), type II (USH2A and USH2B) and type III (USH3). The type I is the most severe form. Gene loci responsible for these three types are all mapped. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Function:
May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.

Subcellular Location:
Cytoplasm; cytoskeleton.

Tissue Specificity:
Ubiquitous; expressed in most tissues with the exception of thymus and peripheral blood lymphocytes.

Similarity:
Belongs to the WD repeat EMAP family.
Contains 10 WD repeats.