Anti-EIF2D抗体HCA56 is a 584 amino acid peripheral membrane protein belonging to the ligatin family.

产品编号 yb-14539R
英文名称 Anti-EIF2D抗体
中文名称 EIF2D蛋白抗体
别    名 Eukaryotic translation initiation factor 2D; HCA56; Hepatocellular carcinoma associated antigen 56; Hepatocellular carcinoma-associated antigen 56; LGTN; LIGA_HUMAN; Ligatin; OTTHUMP00000034537; OTTHUMP00000034538.
Anti-EIF2D抗体
说 明 书 0.1ml  0.2ml  
研究领域 细胞生物  发育生物学  转运蛋白  细胞粘附分子  细胞分化  新陈代谢  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 65kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human EIF2D
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
HCA56 is a 584 amino acid peripheral membrane protein belonging to the ligatin family. Expressed during embryonic development and in early differentiated states, ligatin is a trafficking receptor for phosphoglycoproteins. Ligatin localizes to phosphoglycoproteins within endosomes and at the cell periphery where it participates in specific metabolic processes as well as intercellular adhesion. Involved in RNA binding and translation initiation through its single PUA domain and SUI1 domain, ligatin is down-regulated with long-lasting effects by the activation of Ca2+ dependent N-methyl-D-aspartate (NMDA) subclass of excitatory amino acid (EAA) receptors. Ligatin is considered a marker protein for membrane-vesicle transport systems. Ligatin exists as two alternatively splice variants and is encoded by a gene located on human chromosome 1.

Function:
Trafficking receptor for phosphoglycoproteins. Localizes phosphoglycoproteins within endosomes and at the cell periphery where they participate in specific metabolic processes as well as intercellular adhesion.

Subcellular Location:
Membrane.

Similarity:
Belongs to the ligatin family.
Contains 1 PUA domain.
Contains 1 SUI1 domain.