Anti-EFCAB4A抗体EF-CAB4A is a 399 amino acid protein belonging to the EFCAB4 family. Containing two EF-hand domains,

产品编号 yb-14511R
英文名称 Anti-EFCAB4A抗体
中文名称 EFCAB4A蛋白抗体
别    名 EF-CAB4A; Calcium release-activated calcium channel regulator 2B; CRAC channel regulator 2B; CRACR2B; EF-hand calcium-binding domain-containing protein 4A; EFC4A_HUMAN; Efcab4a.
 Anti-EFCAB4A抗体
说 明 书 0.2ml  
研究领域 细胞生物  信号转导  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Horse, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 45kDa
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human EFCAB4A
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
 
PubMed PubMed
产品介绍 background:
EF-CAB4A is a 399 amino acid protein belonging to the EFCAB4 family. Containing two EF-hand domains, EF-CAB4A may be involved in store-operated Ca2+ entry (SOCE). EF-CAB4A exists as three alternatively spliced isoforms, and is encoded by a gene mapping to human chromosome 11p15.5. With approximay 135 million base pairs and 1,400 genes, chromosome 11 makes up around 4% of human genomic DNA and is considered a gene and disease association dense chromosome. Wilms' tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11.

Function:
Plays a role in store-operated Ca(2+) entry (SOCE).
 
Similarity:
Belongs to the EFCAB4 family.
Contains 2 EF-hand domains.