Anti-EDDM3A抗体Testicular sperm are morphologically differentiated but are not progressively motile nor able to fertilize an egg.

产品编号 yb-14499R
英文名称 Anti-EDDM3A抗体
中文名称 附睾蛋白3A抗体
别    名 EP3A; Epididymal protein 3A; Epididymal secretory protein E3 alpha; Epididymis specific 3 alpha; FAM12A; EP3A_HUMAN; Family with sequence similarity 12 member A; HE3 ALPHA; HE3A; HE3ALPHA; Human epididymis specific 3 alpha; Human epididymis specific protein 3 alpha.
Anti-EDDM3A抗体  
说 明 书 0.2ml  
研究领域 细胞生物  发育生物学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 15kDa
细胞定位 细胞浆 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human EDDM3A
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
Testicular sperm are morphologically differentiated but are not progressively motile nor able to fertilize an egg. Post-testicular maturation requires exposure of spermatozoa to the microenvironment of the epididymal lumen. Spermatozoa undergo extensive changes in the epididymis, including enzymatic modifications, loss of pre-existing components and addition of new glycoproteins from epididymal secretions. These modifying proteins and enzymes are synthesized by epithelial cells lining the epididymal duct and secreted apically into the lumen, where they come into contact with, and may be absorbed onto, the sperm membranes. The proteins encoded by the genes in this cluster are synthesized and secreted by epididymal epithelial cells. [provided by RefSeq, Jul 2008]

Function:
Possible function in sperm maturation. 

Subcellular Location:
Secreted

Tissue Specificity:
Epididymis, with predominant expression in the corpus region. Moderay expressed in the vas deferens; only low levels are detectable in the caput and cauda regions.