Anti-EVC2抗体EMSY binds BRCA2 within a region （exon 3） deleted in cancer. EMSY is capable of silencing the activation potential of BRCA2 exon 3,

产品编号 yb-13069R
英文名称 Anti-EVC2抗体
中文名称 EMSY蛋白抗体
别    名 C11orf30; Chromosome 11 open reading frame 30; EMSY protein; FLJ90741; GL002; Protein EMSY; EMSY_HUMAN.
Anti-EVC2抗体   
说 明 书 0.1ml  0.2ml  
研究领域 肿瘤  细胞生物  转录调节因子  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 141kDa
细胞定位 细胞核 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human EMSY
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 Anti-EVC2抗体
PubMed PubMed
产品介绍 background:
EMSY binds BRCA2 within a region (exon 3) deleted in cancer. EMSY is capable of silencing the activation potential of BRCA2 exon 3, associates with chromatin regulators HP1 and BS69, and localizes to sites of repair following DNA damage. Its levels are amplified in breast and ovarian cancer.

Function:
Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2. 

Subunit:
Homodimer. Interacts with the transactivation domain of BRCA2. Interacts with the chromoshadow domain of CBX1 and with ZMYND11. Does not interact with CBX3 or CBX5. 

Subcellular Location:
Nuclear. Localizes to DNA damage markers in irradiated cells; suggesting that it participates in the DNA repair process.

Similarity:
Contains 1 ENT (EMSY N-terminal) domain. 

Database links:
UniProtKB/Swiss-Prot: Q7Z589.2
Anti-EVC2抗体
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.