Anti-EAA1抗体Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity,

产品编号 yb-12560R
英文名称 Anti-EAA1抗体
中文名称 *受体KA1抗体
别    名 EAA 1; EAA1; Excitatory amino acid receptor 1; Glutamate receptor; Glutamate receptor ionotropic kainate 4; Glutamate receptor ionotropic kainate 4 precursor; Glutamate receptor KA 1; Glutamate receptor KA 1precursor; Glutamate receptor KA-1; Glutamate receptor KA1; Glutamate receptor, ionotropic kainate 4; GRIK 4; GRIK; GRIK4; GRIK4_HUMAN; ionotropic kainate 4; KA 1; KA1; OTTHUMP00000045951; OTTHUMP00000231881.
Anti-EAA1抗体
说 明 书 0.1ml  0.2ml  
研究领域 神经生物学  通道蛋白  细胞膜受体  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 105kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human EAA1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Kainate/AMPA receptors are co-localized with NMDA receptors in many synapses and consist of the structurally related subunits GluR-1 to -7, KA1 and KA2. KA1 (also designated EEA1) and KA2 (also designated EEA2) form heteromeric receptors with GluR subunits when coexpressed, forming ion channels with various properties . The kainate/AMPA receptors are primarily responsible for the fast excitatory neuro-transmission by glutamate.

Function:
Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.

Subunit:
Forms a heteromeric channel with GRIK1 or GRIK3. 

Subcellular Location:
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. 

Similarity:
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK4 subfamily.

Database links:
UniProtKB/Swiss-Prot: Q16099.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.