Anti-EAR1抗体Eosinophil derived neurotoxin （EDN） is a protein belonging to the ribonuclease （RNase） A superfamily.

产品编号 yb-1754R
英文名称 Anti-EAR1抗体
中文名称 嗜酸性粒细胞阳离子蛋白抗体
别    名 ECP1_MOUSE; Cytotoxic ribonuclease; Eosinophil cationic protein 1; Eosinophil secondary granule ribonuclease 1; EAR-1; Ribonuclease 3-1; RNase 3-1; eosinophil cationic protein 1 precursor; Ear1; ECP 1.
Anti-EAR1抗体    
说 明 书 0.1ml  0.2ml  
研究领域 细胞生物  免疫学  通道蛋白  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse, Rat, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 14kDa
细胞定位 分泌型蛋白 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse Eosinophil cationic protein 1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
Eosinophil derived neurotoxin (EDN) is a protein belonging to the ribonuclease (RNase) A superfamily. It has recently been found to have antiviral activity against respiratory syncytial virus and human immunodeficiency virus in vitro.

Function:
Cytotoxin and helminthotoxin with ribonuclease activity. Possesses a wide variety of biological activities.

Subunit:
Interacts with bacterial lipopolysaccharide (LPS) and lipoteichoic acid (LTA). In vitro interacts with and insert into lipid bilayers composed of dioleoyl phosphatidylcholine and dioleoyl phosphatidylglycerol. In vitro, tends to form amyloid-like aggregates at pH 3, but not at pH 5, nor 7.

Subcellular Location:
Secreted. Note=Located in the matrix of eosinophil large specific granule, which are released following activation by an immune stimulus.