Anti-EAAT3抗体This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes.

产品编号 yb-1752R
英文名称 Anti-EAAT3抗体
中文名称 胶质细胞*运载蛋白3/神经/上皮细胞*运载蛋白抗体
别    名 Excitatory amino acid transporters 3; Slc1a1; Eaac1; Eaat3; SLC1A1; EAAC1; EAAT3; solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1; EAAC 2; Excitatory amino acid carrier 1; Excitatory amino acid carrier 2; Excitatory amino acid carrier1; MEAAC 1; MEAAC1; Neuronal and epithelial glutamate transporter; REAAC 1; REAAC1; Slc1 a1; Slc1a 1; Slc1a1; Sodium dependent glutamate/aspartate transporter 3; Solute carrier family 1, member 1; EAA3_HUMAN.
Anti-EAAT3抗体
说 明 书 0.1ml  0.2ml  
研究领域 免疫学  神经生物学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 58kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human EAAT3
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect.

Function:
Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity).

Subunit:
Interacts with ARL6IP5/PRAF3.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Expressed in all tissues tested including liver, muscle, testis, ovary, retinoblastoma cell line, neurons and brain (in which there was dense expression in substantia nigra, red nucleus, hippocampus and in cerebral cortical layers).