Anti-DYNLRB1抗体This gene is a member of the roadblock dynein light chain family. The encoded cytoplasmic protein is capable of binding

产品编号 yb-14470R
英文名称 Anti-DYNLRB1抗体
中文名称 胞质动力蛋白轻链抗体2A抗体
别    名 BITH; bithoraxoid like protein; BLP; cytoplasmic dynein light chain 2A; DNCL2A; DNLC2A; dynein associated protein HKM23; dynein associated protein Km23; Dynein light chain 2A, cytoplasmic; dynein, cytoplasmic, light polypeptide 2A; dynein, light chain, roadblock type 1; HSPC162; Roadblock 1; DLRB1_HUMAN; roadblock domain containing 1; Roadblock domain containing protein 1; ROBL/LC7 like 1; ROBLD1.
Anti-DYNLRB1抗体    
说 明 书 0.2ml  
研究领域 肿瘤  细胞生物  信号转导  细胞类型标志物  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Rabbit, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 11kDa
细胞定位 细胞浆 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human DYNLRB1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
This gene is a member of the roadblock dynein light chain family. The encoded cytoplasmic protein is capable of binding intermediate chain proteins, interacts with transforming growth factor-beta, and has been implicated in the regulation of actin modulating proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 12 and 18. [provided by RefSeq, Aug 2013]

Function:
DYNLRB1 is a member of the roadblock dynein light chain family and encodes a cytoplasmic protein that is capable of binding intermediate chain proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression.

Subcellular Location:
Cytoplasmic

Tissue Specificity:
High expression in heart, liver, brain and pancreas; moderate in placenta, skeletal muscle and kidney; low in lung, prostate, testis, small intestine and colon. Isoform 1 expression is up-regulated in 64% hepatocellular carcinoma (HCC) patients.