Anti-DNHD1抗体Dyneins are multisubunit, high molecular weight ATPases that interact with microtubules to generate force

产品编号 yb-14398R
英文名称 Anti-DNHD1抗体
中文名称 DNHD1蛋白抗体
别    名 C11orf47; CCDC35; coiled-coil domain containing 35; DHCD1; DNHD1; DNHD1 variant protein; DNHD1_HUMAN; DNHD1L; Dynein heavy chain domain 1-like protein; Dynein heavy chain domain-containing protein 1; FLJ32752; FLJ35709; FLJ46184; Protein CCDC35.
Anti-DNHD1抗体   
说 明 书 0.2ml  
研究领域 细胞生物  信号转导  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, 
产品应用 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 533kDa
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human DNHD1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
Dyneins are multisubunit, high molecular weight ATPases that interact with microtubules to generate force by converting the chemical energy of ATP into the mechanical energy of movement. Cytoplasmic or axonemal Dynein heavy, intermediate, light and light-intermediate chains are all components of minus end-directed motors; the complex transports cellular cargos towards the central region of the cell. Axonemal dynein motors contain one to three non-identical heavy chains and cause a sliding of microtubules in the axonemes of cilia and flagella in a mechanism necessary for cilia to beat and propel the cell. DNHD1 is a 4,753 amino acid member of the dynein heavy chain protein family. Phosphorylated upon DNA damage, DNHD1 contains 12 LRR (leucine-rich) repeats. The gene that encodes DNHD1 maps to human chromosome 11, which contains 135 million base pairs and 1,400 genes.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.