Anti-DNAH12抗体Dyneins are multisubunit, high molecular weight ATPases that interact with microtubules to generate force by converting

产品编号 yb-14361R
英文名称 Anti-DNAH12抗体
中文名称 轴丝动力蛋白12抗体
别    名 DYH12_HUMAN; Dynein heavy chain 12, axonemal; Axonemal beta dynein heavy chain 12; Axonemal dynein heavy chain 12-like protein; Axonemal dynein heavy chain 12 like protein; Axonemal dynein heavy chain 7-like protein; Ciliary dynein heavy 12; Dynein heavy chain 7-like, axonemal; Axonemal dynein heavy chain 7 like protein; Dynein heavy chain domain-containing protein 2; DHC3; DLP12; DNAH12L; DNAH7L; DNAHC3; DNHD2; HDHC3; HL19.
 Anti-DNAH12抗体  
说 明 书 0.2ml  
研究领域 细胞生物  信号转导  细胞骨架  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Rabbit, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 357kDa
细胞定位 细胞浆 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human DNAH12
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
 
PubMed PubMed
产品介绍 background:
Dyneins are multisubunit, high molecular weight ATPases that interact with microtubules to generate force by converting the chemical energy of ATP into the mechanical energy of movement. Cytoplasmic or axonemal dynein heavy, intermediate, light and light-intermediate chains are all components of minus end-directed motors; complexes that transport cellular cargo toward the central region of the cell. Axonemal dynein motors contain one to three non-identical heavy chains and cause a sliding of microtubules in the axonemes of cilia and flagella in a mechanism necessary for cilia to beat and propel the cell. DNAH12 is a 3,092 amino acid protein of cilium axoneme that exists as three alternatively spliced isoforms. A member of the dynein heavy chain family, DNAH12L is involved in sperm flagellar assembly and is encoded by a gene located on human chromosome 3.
 
Function:
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thou