Anti-DMRTC1抗体DMRTC1 is a 182 amino acid nuclear protein that exists as three alternatively spliced isoforms and belongs to the DMRT family.

产品编号yb-14350R
英文名称 Anti-DMRTC1抗体
中文名称 DMRTC1蛋白抗体
别    名 DMRT like family C1; Dmrtc1; DMRTC_HUMAN; DMRTC1B; Doublesex and mab 3 related transcription factor C1; Doublesex mab 3.
 Anti-DMRTC1抗体  
说 明 书 0.1ml  0.2ml  
研究领域 细胞生物  转录调节因子  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 20kDa
细胞定位 细胞核 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human DMRTC1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
 
PubMed PubMed
产品介绍 background:
DMRTC1 is a 182 amino acid nuclear protein that exists as three alternatively spliced isoforms and belongs to the DMRT family. Involved in sexual development, DMRTC1 is expressed in Sertoli cells in male testis but, unlike other DMRT family members, it does not contain a DM DNA-binding domain. The gene encoding DMRTC1 maps to the human X chromosome, which consists of about 153 million base pairs and nearly 1,000 genes. The combination of an X and Y chromosome lead to normal male development while two copies of X lead to normal female development. There are a number of conditions related to an unsual number and combination of sex chromosomes being inherited, including Klinefelter's syndrome, Turner's syndrome, and Triple X syndrome.
 
Function:
The vertebrate DMRT gene family encodes putative transcription factors related to the sexual regulators Doublesex (Drosophila) and MAB-3 (Worm).