Anti-DHFRL1抗体May play a role in folate metabolism. Belongs to the dihydrofolate reductase family.

产品编号 yb-9670R
英文名称 Anti-DHFRL1抗体
中文名称 二氢*还原酶样1抗体
别    名 DHFRP4; Dihydrofolate reductase like 1; Dihydrofolate reductase pseudogene 4; DYRL1_HUMAN.
Anti-DHFRL1抗体   
说 明 书 0.1ml  0.2ml  
研究领域 肿瘤  细胞生物  信号转导  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 21kDa
细胞定位 细胞浆 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human DHFRL1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
May play a role in folate metabolism. Belongs to the dihydrofolate reductase family. 

Function:
Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Binds its own mRNA and that of DHFR.

Subcellular Location:
Mitochondrion. Mitochondrion matrix. Mitochondrion inner membrane. 

Tissue Specificity:
Expressed in numerous cell lines. 

Similarity:
Belongs to the dihydrofolate reductase family. 
Contains 1 DHFR (dihydrofolate reductase) domain.

Database links:

Entrez Gene: 200895 Human

SwissProt: Q86XF0 Human

Unigene: 718516 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.