Anti-DENND2D抗体DENND2D is a 471 amino acid protein that contains a dDENN domain, a DENN domain, and a uDENN domain and exists as two isoforms

产品编号 yb-9668R
英文名称 Anti-DENND2D抗体
中文名称 DENN域内含蛋白2D抗体
别    名 DEN2D_HUMAN; DENN domain-containing protein 2D; DENN/MADD domain containing 2D; DENND2D.
Anti-DENND2D抗体  
说 明 书 0.2ml  
研究领域
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 54 kDa
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human DENND2D
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
DENND2D is a 471 amino acid protein that contains a dDENN domain, a DENN domain, and a uDENN domain and exists as two isoforms as a result of alternative splicing. The DENND2D protein is thought to target to actin filaments and control Rab9-dependent trafficking of mannose-6-phosphate receptor to lysosomes. The gene encoding DENND2D maps to human chromosome 1, the largest human chromosome which spans about 260 million base pairs and makes up 8% of the human genome. Other notable genes located on chromosome 1 include LMNA, which is associated with the rare aging disease Hutchinson-Gilford progeria, and the MUTYH gene, which is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome.

Function:
Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.

Similarity:
Contains 1 dDENN domain. 
Contains 1 DENN domain. 
Contains 1 uDENN domain. 

Database links:
UniProtKB/Swiss-Prot: Q9H6A0.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.