Anti-CDSCC1抗体Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks.

产品编号 yb-7720R
英文名称 Anti-CDSCC1抗体
中文名称 DSCC1蛋白抗体
别    名 DCC1; DCC1_HUMAN; Defective in sister chromatid cohesion 1 homolog; Defective in sister chromatid cohesion protein 1 homolog; DSCC1; hDCC1; MGC5528; Sister chromatid cohesion protein DCC1.
Anti-CDSCC1抗体 
说 明 书 0.1ml  0.2ml  
研究领域 细胞生物  细胞周期蛋白  细胞分化  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 45kDa
细胞定位 细胞核 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human DSCC1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3.

Function:
Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3.

Subunit:
Component of the CTF18-RFC complex which consists of CTF8, CTF18, DSCC1 and the RFC complex. Interacts with CTF8 and CTF18.

Subcellular Location:
Nucleus.

Similarity:
Belongs to the DCC1 family.

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.