Anti-DUSP2抗体DUSP2 is a dual-specific thr/tyr phosphatase that is a physiologically relevant MAP kinase phosphatase.

产品编号 byb-7609R
英文名称 Anti-DUSP2抗体
中文名称 双特异性磷酸酶2抗体
别    名 Dual specificity phosphatase 2; Dual specificity protein phosphatase 2; Dual specificity protein phosphatase PAC 1; DUSP 2; PAC 1; PAC1; Serine/threonine specific protein phosphatase; DUS2_HUMAN.
Anti-DUSP2抗体  
说 明 书 0.2ml  
研究领域 细胞生物  信号转导  细胞凋亡  细胞周期蛋白  转录调节因子  激酶和磷酸酶  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Sheep, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 34kDa
细胞定位 细胞核 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human DUSP2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
DUSP2 is a dual-specific thr/tyr phosphatase that is a physiologically relevant MAP kinase phosphatase. The gene is located on 2q11.2-q11 and contains 4 exons that span approximay 2.3kb. Under specific stress conditions, p53 regulates transcription of PAC1 through a new p53-binding site, and that PAC1 is necessary and sufficient for p53-mediated apoptosis.

Function:
Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.

Subcellular Location:
Nucleus. 

Tissue Specificity:
Expressed in hematopoietic tissues. 

Similarity:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 
Contains 1 rhodanese domain. 
Contains 1 tyrosine-protein phosphatase domain. 

Database links:
UniProtKB/Swiss-Prot: Q05923.1

Important Note:
This product as supplied is i