Anti-DBC2抗体DBC2 is a member of the recently identified RhoBTB family, which is part of the Rho GTPase family. DBC2 has

产品编号 yb-4274R
英文名称 Anti-DBC2抗体
中文名称 乳腺癌基因删除蛋白2抗体
别    名 DBC 2; Deleted in breast cancer 2; Deleted in breast cancer 2 gene protein; E130206H14Rik; KIAA0717; p83; RBT2; RHBT2_HUMAN; Rho related BTB domain containing 2; Rho related BTB domain containing protein 2; Rho-related BTB domain containing 2; Rho-related BTB domain-containing protein 2; RHOBTB 2; Rhobtb2.
Anti-DBC2抗体   
说 明 书 0.2ml  
研究领域 肿瘤  细胞生物  免疫学  信号转导  细胞周期蛋白  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Horse, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 83kDa
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human DBC2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
DBC2 is a member of the recently identified RhoBTB family, which is part of the Rho GTPase family. DBC2 has been implicated as a tumor suppressor in breast and lung cancer. Studies have shown that DBC2 binds to the ubiquitin ligase scaffold Cul3, and that Cul3 regulates DBC2 protein levels by ubiquitinating DBC2 directly, leading to its degradation by the proteasome.

Tissue Specificity:
Ubiquitous, with highest levels in neural tissues. Expression is also detected in fetal lung, heart, and brain. 

Similarity:
Belongs to the small GTPase superfamily. Rho family.
Contains 2 BTB (POZ) domains. 

Database links:
UniProtKB/Swiss-Prot: Q9BYZ6.2