Anti-DEGS1抗体DEGS1 is a member of the membrane fatty acid desaturase family which is responsible for inserting double bonds into specific positions in fatty acids.

产品编号 yb-4057R
英文名称Anti-DEGS1抗体
中文名称 退行性精母细胞同源物1抗体
别    名 Degenerative spermatocyte homolog 1; Degenerative spermatocyte homolog 1 lipid desaturase; Degenerative spermatocyte homolog lipid desaturase; DEGS 1; DEGS; Des 1; DES1; Dihydroceramide desaturase; FADS7; Membrane fatty acid (lipid) desaturase; Membrane lipid desaturase; MGC5079; MIG15v Migration inducing gene 15 protein; MLD; Sphingolipid delta 4 desaturase; Sphingolipid delta(4) desaturase DES1.DEGS1_HUMAN
Anti-DEGS1抗体    
说 明 书 0.2ml  
研究领域 肿瘤  细胞生物  免疫学  转录调节因子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Rabbit, Sheep, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 35kDa
细胞定位 细胞浆 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human DEGS1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
DEGS1 is a member of the membrane fatty acid desaturase family which is responsible for inserting double bonds into specific positions in fatty acids. It contains three His containing consensus motifs that are characteristic of a group of membrane fatty acid desaturases. It has sphingolipid-delta-4-desaturase activity and converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine).

Function:
Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine).

Subcellular Location:
Mitochondrion. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
Myristoylation can target the enzyme to the mitochondria leading to an increase in ceramide levels.