Anti-DC-SIGN抗体Dendritic cells （DCs） that control immune responses were recently found to capture and transport HIV from the mucosal

产品编号 yb-2557R
英文名称 Anti-DC-SIGN抗体
中文名称 细胞间粘附分子非整合素蛋白3抗体
别    名 CLEC4L; Dendritic cell-specific ICAM-3-grabbing non-integrin 1; C type lectin domain family 4 member L; CD 209; CD209; CD209 antigen; CD209 antigen-like protein A; CD209 molecule; Cd209a; CDSIGN; CIRE; DC SIGN1; DCSIGN; Dendritic cell specific ICAM 3 grabbing nonintegrin 1; Dendritic cell specific ICAM3 grabbing nonintegrin 1; Dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin; Dengue fever, protection against, included; Dentritic Cell Specific ICAM3 Grabbing Nonintegrin; HIV GP120 Binding Protein; MGC129965; MGC130443; SIGN-R1; SIGNR5; CD209_HUMAN.
Anti-DC-SIGN抗体  
说 明 书 0.1ml  0.2ml  
研究领域 细胞生物  免疫学  微生物学  信号转导  细菌及病毒  细胞粘附分子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, 
产品应用 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 45kDa
细胞定位 细胞膜 分泌型蛋白 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human DC-SIGN
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes, where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV1, HIV2 and SIV bind to DCs via DCSIGN. ICAM3 is the natural ligand for DC-SIGN. A DC-SIGN homologue (termed CD299, DC-SIGNR, L-SIGN and DCSIGN2) was identified recently. DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR. The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.