Anti-ENTPD7抗体LALP1 is a 604 amino acid multi-pass membrane protein that belongs to the GDA1/CD39 NTPase family.

产品编号 yb-14603R
英文名称 Anti-ENTPD7抗体
中文名称 CD39样蛋白2/ENTPD6抗体
别    名 DKFZp667O124; Ectonucleoside triphosphate diphosphohydrolase 7; ENTPD 7; ENTPD7; ENTP7_HUMAN; LALP 1; LALP1; Lysosomal apyrase like protein 1; NTPDase 7; NTPDase7.
Anti-ENTPD7抗体
说 明 书 0.2ml  
研究领域 肿瘤  细胞生物  信号转导  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Rabbit, Sheep, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 69kDa
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human ENTPD7
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
LALP1 is a 604 amino acid multi-pass membrane protein that belongs to the GDA1/CD39 NTPase family. Preferentially hydrolyzing nucleoside 5’-triphosphates, LALP1 and has an order of activity with respect to possible substrates, which is UTP > GTP > CTP. The gene that encodes LALP1 consists of approximay 51,740 bases and maps to human chromosome 10q24.2. Spanning nearly 135 million base pairs, chromosome 10 makes up approximay 4.5% of total DNA in cells and encodes nearly 1,200 genes. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman’s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria.

Function:
The ENTPD7 belongs to the GDA1/CD39 NTPase family and the gene resides on chromosome 10q23-q24 and contains 12 exons and 11 introns covering a genomic region of approximay 46 kilobase pairs. The subcellular localization and enzymatic activity of ENTPD7 indicated that ENTPD7 is indeed an endo-apyrase with substrate preference for nucleoside triphosphates UTP, GTP, and CTP. 

Subcellular Location:
Cytoplasmic intracellular multi-pass membrane protein. Localizes to vesicular compartments.