Anti-CR16抗体CR16 is a 483 amino acid proline-rich cytoplasmic protein that is thought to regulate cytoskeletal organization.

产品编号 yb-14041R
英文名称 Anti-CR16抗体
中文名称 糖皮质激素区域表达蛋白16抗体
别    名 Corticosteroids and regional expression protein 16 homolog; WAS/WASL-interacting protein family member 3; Wipf3; WIPF3_HUMAN.
Anti-CR16抗体  
说 明 书 0.1ml  0.2ml  
研究领域 细胞生物  神经生物学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Horse, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 49kDa
细胞定位 细胞浆 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CR16
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
CR16 is a 483 amino acid proline-rich cytoplasmic protein that is thought to regulate cytoskeletal organization. A member of both the verprolin and Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP) families, CR16 colocalizes with N-WASP (Neuronal Wiskott-Aldrich syndrome protein) in tips of growth cone filopodia, primary hippocampal neurons and Sertoli cell-spermatid junctions. CR16 and N-WASP functionally interact to influence spermatogenesis. CR16 is predominantly expressed in brain and testis, contains one WH2 domain, a KLKR motif, three profilin-binding motifs and is encoded by a gene that maps to human chromosome 7p15.1.

Function:
May be a regulator of cytoskeletal organization. May have a role in spermatogenesis.

Subcellular Location:
Cytoplasm. In hippocampal neurons colocalizes with WASL in the cell body, axons and the growth cone.

Similarity:
Belongs to the verprolin family.
Contains 1 WH2 domain.

Gene ID:
644150

Database links:

Entrez Gene: 644150 Human

SwissProt: A6NGB9 Human

Unigene: 709280 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.