Anti-CPAMD8抗体CPAMD8 belongs to the complement component-3 （C3; MIM 120700）/alpha-2-macroglobulin （A2M; MIM 103950） family of proteins,

产品编号 yb-14018R
英文名称 Anti-CPAMD8抗体
中文名称 CPAMD8蛋白抗体
别    名 C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8; CPAMD8; CPMD8_HUMAN; K CAP; VIP.
Anti-CPAMD8抗体 
说 明 书 0.1ml  0.2ml  
研究领域 细胞生物  免疫学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Dog, Cow, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 204kDa
细胞定位 细胞浆 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CPAMD8
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
CPAMD8 belongs to the complement component-3 (C3; MIM 120700)/alpha-2-macroglobulin (A2M; MIM 103950) family of proteins, which are involved in innate immunity and damage control. Complement components recognize and eliminate pathogens by direct binding or by mediating opsonization/phagocytosis and intracellular killing, and A2M is a broad-spectrum protease inhibitor (Li et al., 2004 [PubMed 15177561]).[supplied by OMIM, Mar 2008]

Function:
Highly expressed in the kidney, brain and testis and to a lower extent in heart, liver and small intestine.

Subcellular Location:
Secreted. Cell membrane.

Post-translational modifications:
Proteolytically cleaved into 2 chains of about 70 and 130 kDa. The fragments are not connected by disulfide bonds.

Similarity:
Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
Contains 1 Kazal-like domain.