Anti-CENTG3抗体ADP-ribosylation factor （ARF） family of small GTP-binding proteins are involved in vesicular transport regulation and in controlling cytoskeletal

产品编号 yb-13846R
英文名称 Anti-CENTG3抗体
中文名称 CENTG3蛋白抗体
别    名 AGAP-3; Agap3; AGAP3_HUMAN; ANK repeat and PH domain-containing protein 3; Arf GAP with GTPase, ANK repeat and PH domain containing protein 3; Arf-GAP with GTPase; ArfGAP with GTPase domain, ankyrin repeat and PH domain; ArfGAP with GTPase domain, ankyrin repeat and PH domain 3; centaurin gamma 3; Centaurin-gamma-3; CENTG3; Cnt-g3; CRAG; CRAM-associated GTPase; CRMP (collapsin response mediator protein) associated; FLJ16146; FLJ34452; MR1-interacting protein; MRIP-1; MRIP1; OTTHUMP00000213333; OTTHUMP00000213334; OTTHUMP00000213335; OTTHUMP00000213336.
Anti-CENTG3抗体  
说 明 书 0.1ml  0.2ml  
研究领域 细胞生物  信号转导  G蛋白信号  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 95kDa
细胞定位 细胞浆 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CENTG3
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
ADP-ribosylation factor (ARF) family of small GTP-binding proteins are involved in vesicular transport regulation and in controlling cytoskeletal organization and cell adhesion. These proteins are best characterized as regulators of membrane traffic. The Centaurin GTPase-activating protein family comprise a subset of ARF regulatory molecules that transduce PI 3-kinase activation into coordinated control of Arf-dependent pathways. This family includes ASAP1, ACAP1, ACAP2, AGAP1, ARAP1, ARAP2, Centaurin a1 and Centaurin g3. The Centaurin a1 protein is a high affinity PtdIns(3,4,5)P3 binding protein enriched in brain. By acting as a GTPase activating protein for ADP ribosylation factor 6 (ARF6), Centaurin a1 is able to switch off ARF6 and inhibit its ability to mediate b2-adrenoceptor internalization and negatively regulate ARF6 activity by functioning as an in vivo PIP3 dependent ARF6 GAP OTTHUMP00000213337; domain, five PH domains, one Ras-associating domain, one Rho-GAP domain and one SAM (sterile a motif) domain.

Function:
GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway.