Anti-CD80抗体CD80 is a member of the Ig superfamily and serves as the ligand for two T cell molecules,

产品编号 yb-10340R
英文名称 Anti-CD80抗体
中文名称 CD80抗体
别    名 B7; T-lymphocyte activation antigen CD80 precursor; counter-receptor for CD28 and CD152 (CTLA4; T-cell co-stimulatory protein B7-1; B7-1 protein; B7-1; CD80; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); Q9N0T0_CANFA; T-cell co-stimulatory protein B7-1.
 Anti-CD80抗体   
说 明 书 0.2ml  
研究领域
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Dog, 
产品应用 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 31kDa
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD80/B7-1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
 
PubMed PubMed
产品介绍 background:
CD80 is a member of the Ig superfamily and serves as the ligand for two T cell molecules, CD28 and CTLA4. Interactions between CD28 and CD80 on activated B cells result in enhanced T cell activation. CD80 is rapidly induced on the surface of in vitro activated B cells, Epstein Barr Virus (EBV) transformed B cell lines, Burkitts lymphoma cell lines, freshly isolated follicular B lymphoma cells, T cells, and monocytes. It is also expressed at high levels in dendritic cells. It reacts weakly with a small proportion of non activated normal B cells and with HTLV1 infected T cells. CD80 does not react with peripheral monocytes, resting and activated normal T cells, T cell lines and T cell clones, nor with myelomonocytic cell lines. 

Function:
Involved in the costimulatory signal essential for T lymphocytes activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Similarity:
Contains 1 Ig-like C2-type (immunoglobulin-like) domain. 
Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Database links:
Entrez Gene: 403765 Dog
 
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.