Anti-C1RL抗体Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum.

产品编号 yb-15087R
英文名称 Anti-C1RL抗体
中文名称 补体C1RL链多肽抗体
别    名 C1r like protein; C1r like serine protease analog; C1r like serine protease analog protein; C1r LP; C1r-like protein; C1r-like serine protease analog protein; C1r-LP; C1rl; C1RL_HUMAN; C1RL1; C1RLP; CLSPa; complement C1r like proteinase; Complement C1r subcomponent-like protein; Complement component 1 r subcomponent like.
Anti-C1RL抗体 
说 明 书 0.2ml  
研究领域 细胞生物  免疫学  信号转导  转运蛋白  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 49kDa
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human C1RL
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
No data available.

Function:
Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum.

Subcellular Location:
Secreted.

Tissue Specificity:
Highly expressed in placenta, liver, kidney, pancreas, moderay in lung, spleen, prostate, ovary, colon, and PBL, and weakly in heart, skeletal muscle, thymus, testis, and small intestine. Expressed in PC-3 (prostate adenocarcinoma) and SK-OV-3 (ovary adenocarcinoma) cells, but not in LoVo and HT-29 (colon adenocarcinoma), SMMC7721 (hepatocellular carcinoma), CaoV-3 (ovary adenocarcinoma), HeLa (cervix epithelioid carcinoma), MCF-7 (breast adenocarcinoma), U-251MG (glioma) or A-549 (lung carcinoma) cells. Widely expressed in myeloid leukemia cell lines, including K-562 (chronic myelogenous leukemia), THP-1 (myelomonocytic leukemia), HL-60 and NB4 (promyelocytic leukemia), and KG-1 (acute myelogenous leukemia) cells. Expressed mainly in the liver and in serum (at protein level). 

Similarity:
Belongs to the peptidase S1 family. 
Contains 1 CUB domain. 
Contains 1 peptidase S1 domain. 


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.