Anti-Capsid protein VP1抗体是由Toolan（1960）从经大鼠传代的人肿瘤细胞系（HEP-1）分离到得第2株大鼠细小病毒（RPV）,通常称为H-1病毒,又称Toolan病毒。

产品编号 yb-4649R
英文名称 Anti-Capsid protein VP1抗体
中文名称 大鼠细小病毒H-1株(H-1)抗体
别    名 Parvovirus h-1 coat; CAPSD_PAVHH; Capsid protein VP1; Coat protein VP1.
Anti-Capsid protein VP1抗体
说 明 书 0.1ml  0.2ml  
研究领域 细胞生物  免疫学  细菌及病毒  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Murine minute virus (H-1 parvovirus)
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 81kDa
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse Capsid protein VP1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 Function:
Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of two size variants of the capsid proteins, VP1 and VP2, which differ by the presence of an N-terminal extension in the minor protein VP1. The capsid encapsulates the genomic ssDNA. Capsid proteins are responsible for the attachment to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Binding to the host receptors also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and putative nuclear localization signal(s). VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell and might contribute to virus transport to the nucleus (By similarity).

Subcellular Location:
Virion (By similarity). Host nucleus (Potential). 

Similarity:
Belongs to the parvoviridae capsid protein family. 

Database links:
UniProtKB/Swiss-Prot: P03136.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

是由Toolan(1960)从经大鼠传代的人肿瘤细胞系(HEP-1)分离到得第2株大鼠细小病毒(RPV),通常称为H-1病毒,又称Toolan病毒。