Anti-CNTN4/AXCAM抗体Contactin 4 is a 1,026 amino acid protein encoded by the human gene CNTN4. Contactin 4 belongs to the immunoglobulin superfamily and is a member of the

产品编号 byb-11074R
英文名称Anti-CNTN4/AXCAM抗体
中文名称 轴突相关粘附分子抗体
别    名 BIG 2; CNTN4A; AXCAM; Axonal associated cell adhesion molecule; BIG-2; Brain derived immunoglobulin superfamily protein 2; Brain-derived immunoglobulin superfamily protein 2; Cntn4; CNTN4_HUMAN; contactin 4; Contactin-4; Neural cell adhesion protein BIG 2; SCA16.
Anti-CNTN4/AXCAM抗体
说 明 书 0.2ml  
研究领域 神经生物学  细胞粘附分子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Sheep, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 109kDa
细胞定位 细胞膜 分泌型蛋白 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CNTN4/AXCAM
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
Contactin 4 is a 1,026 amino acid protein encoded by the human gene CNTN4. Contactin 4 belongs to the immunoglobulin superfamily and is a member of the Contactin family. Contactin 4 contains four fibronectin type-3 domains, six Ig-like C2-type domains, and has three isoforms (1,2,3). Defects in the CNTN4 gene are a cause of 3p deletion syndrome (3PDS). 3PDS is a rare contiguous gene disorder involving the loss of the omeric portion of the short arm of chromosome 3 and is characterized by developmental delay, growth retardation, and dysmorphic features. Contactin 4 is primarily expressed in brain tissue. Highest expression has been found to be in the cerebellum, with lowest levels found in corpus callosum, caudate nucleus, amygdala and spinal cord. Some expression is also found in testis, pancreas, thyroid, uterus, small intestine and kidney. Contactin 4 is not believed to be expressed in skeletal muscle. Isoform 2 is weakly expressed in cerebral cortex.

Function:
Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis.