Ant-CREG2抗体The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. CREG （cellular repressor of E1A-stimulated genes） is a

产品编号 yb-9957R
英文名称 Ant-CREG2抗体
中文名称 E1A激活基因刺激蛋白2抗体
别    名 CREG 2; CREG-2; Cellular repressor of E1A stimulated genes 2; CREG2_HUMAN.
Ant-CREG2抗体   
说 明 书 0.1ml  0.2ml  
研究领域 细胞生物  免疫学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 29kDa
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CREG2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.

PubMed PubMed
产品介绍 background:
The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. CREG (cellular repressor of E1A-stimulated genes) is a cellular protein that antagonizes transcriptional activation and cellular transformation by E1A. CREG was initially isolated in a yeast two-hybrid screen due to its interaction with the TATA-binding protein, TBP. A member of the CREG family, CREG2 (cellular repressor of E1A-stimulated genes 2) is a novel protein that shares 35% homology with CREG and is expressed at highest levels in brain. CREG2 is a secreted protein containing 290 amino acids whose N-terminus is thought to function as a signal sequence. The gene encoding CREG2 maps to human chromosome 2, which consists of 237 million bases, encodes over 1,400 genes and makes up approximay 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2 including Harlequin icthyosis, sitosterolemia and Alstr鰉 syndrome.


Tissue Specificity:
Brain specific mainly in the limbic system and faintly in the spinal cord but not in cerebellum. 

Post-translational modifications:
It is not sure whether N-glycosylation is on Asn-165 and/or Asn-166. 

Similarity:
Belongs to the CREG family. 

Database links:
UniProtKB/Swiss-Prot: Q8IUH2.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.