Anti-Cyclooxygenase 3抗体Cytochrome c oxidase subunit III, COX3 （also designated COIII, MTCO3 or oxidative phosphorylation （OxPhos） Complex IV,

产品编号 byb-9896R
英文名称 Anti-Cyclooxygenase 3抗体
中文名称 前列腺素过氧化物合成酶3抗体
别    名 Cox-3; Cox 3; Cyclooxygenase 1; Cyclooxygenase 3; Cytochrome c oxidase subunit III; Prostaglandin endoperoxide synthase 3; Ptgs1;COIII; COX3; COX3_HUMAN; COXIII; Cytochrome c oxidase polypeptide III; Cytochrome c oxidase subunit 3; MT CO3; MT-CO3; MTCO3; PGH1_HUMAN.
Anti-Cyclooxygenase 3抗体 
说 明 书 0.1ml  0.2ml  
研究领域 肿瘤  心血管  信号转导  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 66kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Cyclooxygenase 3/Cox3
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
Cytochrome c oxidase subunit III, COX3 (also designated COIII, MTCO3 or oxidative phosphorylation (OxPhos) Complex IV, subunit III) is one of three mitochondrial DNA (mtDNA) encoded subunits (MTCO1-3) of respiratory Complex IV. Cytochrome c oxidase is a hetero-oligomeric enzyme composed of 13 subunits localized to the mitochondrial inner membrane and is the terminal enzyme complex of the electron transport chain. Complex IV catalyzes the reduction of molecular oxygen to water. The energy released is used to transport protons across the mitochondrial inner membrane. The resulting electro-chemical gradient is necessary for the synthesis of ATP. Complex IV contains 13 polypeptides; COX1, COX2 and COX3 (MTCO1-3) make up the catalytic core and are encoded by mtDNA while subunits IV, Va, Vb, VIa, VIb, VIc, VIIa, VIIb, VIIc and VIII are nuclear-encoded. Apoptosis in mammalian cells may be triggered by inhibition of mitochondrial COX. Specifically, reduction of COX3 has been associated with apoptosis and studies have shown that overexpression of COX3 results in a reduction of signals associated with apoptosis.

Function:
May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells.

Subunit:
Homodimer.

Subcellular Location:
Membrane-associated; Microsomal membrane.

Similarity:
Belongs to the prostaglandin G/H synthase family. 
Contains 1 EGF-like domain. 


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.