Anti-Coronin 1a抗体This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximay 40 amino acids typically bracketed by

产品编号 yb-8550R
英文名称 Anti-Coronin 1a抗体
中文名称 肌动蛋白结合蛋白CORO1A抗体
别    名 actin binding protein; CLABP; Clipin A; Clipin-A; CLIPINA; COR1A_HUMAN; CORO1A; coronin 1; Coronin actin binding protein 1A; Coronin like protein A; Coronin like protein p57; coronin, actin binding protein, 1A; Coronin-1A; Coronin-like protein A; Coronin-like protein p57; p57 antibody TACO; Tryptophan aspartate containing coat protein; Tryptophan aspartate-containing coat protein.
 Anti-Coronin 1a抗体
说 明 书 0.1ml  0.2ml  
研究领域 细胞生物  免疫学  神经生物学  信号转导  结合蛋白  细胞骨架  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 51kDa
细胞定位 细胞浆 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Coronin 1a
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
 
PubMed PubMed
产品介绍 background:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximay 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. [provided by RefSeq, Sep 2010]

Function:
May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes. 

 
Subcellular Location:
Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Cytoplasmic vesicle, phagosome membrane. Note=In non-infected macrophages, associated with the cortical microtubule network. In mycobacteria-infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes. Retention on the phagosomal membrane is strictly dependent on mycobacterial viability and not due to impaired acidification.

Tissue Specificity:
Expressed in brain, thymus, spleen, bone marrow and lymph node. Low in lung and gut.

Similarity:
Belongs to the WD repeat coronin family. 
Contains 7 WD repeats.