Anti-CCDC22抗体This gene encodes a protein containing a coiled-coil domain. The mouse orthologous protein has been shown to bind copines,

产品编号 yb-8124R
英文名称 Anti-CCDC22抗体
中文名称 卷曲螺旋结构域蛋白22抗体
别    名 AI481216; CCD22_HUMAN; Ccdc22.
Anti-CCDC22抗体   
说 明 书 0.1ml  0.2ml  
研究领域 细胞生物  免疫学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 71kDa
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from Human CCDC22
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
This gene encodes a protein containing a coiled-coil domain. The mouse orthologous protein has been shown to bind copines, which are calcium-dependent, membrane-binding proteins that may function in calcium signaling. Localization of the orthologous rat protein suggests that it may play a role in neuronal injury response. This human gene has been identified as a novel candidate gene for syndromic X-linked inlectual disability. [provided by RefSeq, Aug 2011]. 

Subunit:
Interacts with CPNE1 and CPNE4 (By similarity). 

Tissue Specificity:
Widely expressed in adult tissues and in fetal liver and brain, with highest levels in prostate and lowest in skeletal muscle.

DISEASE:
Note=May be involved in X-linked syndromic mental retardation (PubMed:21826058). CCDC22 expression has been found to be down-regulated in a family with a phenotype consistent with X-linked syndromic mental retardation, and carrying variant Ala-17. In addition to inlectual disability, affected individuals have cardiac and skeletal abnormalities. 

Similarity:
Belongs to the CCDC22 family. 

Database links:
UniProtKB/Swiss-Prot: O60826.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.