Anti-CNKSR1抗体This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target.

产品编号 yb-8028R
英文名称 Anti-CNKSR1抗体
中文名称 Ras激酶抑制因子连接增强蛋白1抗体
别    名 CNK； CNK homolog protein 1； CNK1； CNKR1_HUMAN； CNKSR1； Connector enhancer of kinase suppressor of ras 1； Connector enhancer of KSR 1； Connector enhancer of KSR like； Connector enhancer of KSR-like； Connector enhancer of KSR1； hCNK1； KSR.
Anti-CNKSR1抗体 
说 明 书 0.2ml  
研究领域 细胞生物  免疫学  信号转导  G蛋白信号  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 80kDa
细胞定位 细胞浆 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CNKSR1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway. [provided by RefSeq, Jul 2008]. 

Function:
May function as an adapter protein or regulator of Ras signaling pathways. 

Subunit:
Interacts with RHO and RALGDS.

Subcellular Location:
Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). 

Post-translational modifications:
Phosphorylated on tyrosine. 

Similarity:
Belongs to the CNKSR family. 
Contains 1 CRIC domain. 
Contains 1 PDZ (DHR) domain. 
Contains 1 PH domain. 
Contains 1 SAM (sterile alpha motif) domain. 

Database links:
UniProtKB/Swiss-Prot: Q969H4.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.