Anti-CLPTM1抗体Clefts of the oral-facial region usually occur in early fetal development and can affect the lip, the soft palate （the soft tissue in the back of the mouth）

产品编号 yb-8018R
英文名称 Anti-CLPTM1抗体
中文名称 唇裂和腭裂相关跨膜蛋白1抗体
别    名 Cleft lip and palate associated transmembrane protein 1; CLPTM 1; HS9; N14; CLPT1_HUMAN.
 Anti-CLPTM1抗体   
说 明 书 0.2ml  
研究领域 细胞生物  免疫学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 76kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CLPTM1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
 
PubMed PubMed
产品介绍 background:
Clefts of the oral-facial region usually occur in early fetal development and can affect the lip, the soft palate (the soft tissue in the back of the mouth) and the hard palate (the roof of the mouth). Cleft lip (with or without cleft palate) is a genetically complex birth defect that occurs in approximay one in every 750-1,000 live births. This is one of the most common birth defects and is multifactorial, with both genetic and environmental causes. Cleft lip- and palate-associated transmembrane protein 1 (CLPTM1) belongs to a family of cleft lip and palate transmembrane proteins. This family also contains cisplatin resistance-related protein (CRR9), which is involved in CDDP-induced apoptosis. The CLPTM1 protein shows strong homology to two Caenorhabditis elegans genes.

Function:
May play a role in T-cell development (By similarity). 

Subcellular Location:
Membrane; Multi-pass membrane protein (Potential). 

Tissue Specificity:
Widely expressed. 

Similarity:
Belongs to the CLPTM1 family. 

Database links:
UniProtKB/Swiss-Prot: O96005.1
 
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.