Anti-CHORDC1抗体Human CHP1 and the C. elegans homolog Chp are CHORD domain-containing proteins that are largely related, and their corresponding genes are evolutionarily

产品编号 byb-6409R
英文名称 Anti-CHORDC1抗体
中文名称 含半*和*丰富域蛋白1抗体
别    名 CHORD containing protein 1; Chord domain containing protein 1; CHORD domain-containing protein 1; CHORD-containing protein 1; CHORDC1; CHP-1; CHP1; CHRD1_HUMAN; Cysteine and histidine rich domain (CHORD) containing 1; Cysteine and histidine rich domain (CHORD) containing, zinc binding protein 1; Cysteine and histidine rich domain containing 1; Cysteine and histidine rich domain containing zinc binding protein 1; Cysteine and histidine-rich domain-containing protein 1; FLJ37289; Protein morgana.
Anti-CHORDC1抗体   
说 明 书 0.1ml  0.2ml  
研究领域 细胞生物  免疫学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 37kDa
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CHORDC1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
Human CHP1 and the C. elegans homolog Chp are CHORD domain-containing proteins that are largely related, and their corresponding genes are evolutionarily conserved among various eukaryotic organisms (1,2). The unique CHORD domain is characterized as 60 amino acids in length, and contains six highly conserved cysteine residues, two histidine residues and a distinct Zn2+-binding domain (3). CHP1 and the other metazoan orthologs have tandem CHORD domains that are located at both the N- and C- termini (1,4). These proteins are implicated in germline development and embryogenesis as mutations affecting the CHORD domain of the nematode protein Chp result in semisterility and embryonic lethality (1,5).

Function:
Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis.

Subunit:
InteractswithHSP90AA1,ROCK1andROCK2.InteractswithHSP90AB1andPPP5C

Tissue Specificity:
Underexpressedinmanybreastandlungcancers.

Similarity:
Contains2CHORDdomains.
Contains1CSdomain. 


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.