Anti-Cyclin T2抗体Regulatory subunit of the cyclin-dependent kinase pair （CDK9/cyclin T） complex, also called positive transcription elongation factor B （P-TEFB）,

产品编号 yb-7891R
英文名称 Anti-Cyclin T2抗体
中文名称 周期素T2抗体
别    名 CCNT2; CCNT2_HUMAN; Cyclin-T2; CycT2; FLJ90560; MGC134840.
Anti-Cyclin T2抗体  
说 明 书 0.2ml  
研究领域 细胞生物  信号转导  细胞周期蛋白  转录调节因子  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 80kDa
细胞定位 细胞核 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Cyclin T2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II).

Function:
Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II).

Subunit:
Associates with CDK9 to form P-TEFb. Isoform 1 and isoform 2 interact with HIV-2 and SIV Tat. Does not bind efficiently to the transactivation domain of the HIV-1 Tat.

Subcellular Location:
Nucleus.

Tissue Specificity:
Ubiquitously expressed.

Similarity:
Belongs to the cyclin family. Cyclin C subfamily.

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.