Anti-CTNNBL1抗体The protein encoded by this gene contains an acidic domain, a putative bipartite nuclear localization signal, a nuclear export signal,

产品编号 yb-7658R
英文名称 Anti-CTNNBL1抗体
中文名称 β连环蛋白样蛋白1抗体
别    名 Beta catenin like 1; Beta catenin like protein 1; Beta-catenin-like protein 1; C20orf33; Catenin beta like 1; Chromosome 20 open reading frame 3; CTBL1_HUMAN; CTNNBL 1; Ctnnbl1; NAP; Nuclear associated protein; nuclear protein NAP; Nuclear-associated protein; NYD SP19; P14 antibody P14L; Testis development protein NYD SP19; Testis development protein NYD-SP19.
Anti-CTNNBL1抗体   
说 明 书 0.2ml  
研究领域 细胞生物  染色质和核信号  细胞凋亡  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 65kDa
细胞定位 细胞核 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CTNNBL1/Beta catenin like 1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
The protein encoded by this gene contains an acidic domain, a putative bipartite nuclear localization signal, a nuclear export signal, a leucine-isoleucine zipper, and phosphorylation motifs. In addition, the encoded protein contains Armadillo/beta-catenin-like repeats, which have been implicated in protein-protein interactions. Although the function of this protein has not been determined, the C-terminal portion of the protein has been shown to possess apoptosis-inducing activity. 

Function:
Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis. 

Subunit:
Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts directly with CWC15 and CDC5L in the complex. Interacts with AICDA; the interaction is important for the antibody diversification activity of AICDA. Interacts with PRPF31 (via its NLS). Interacts (via its N-terminal NLS) with KPNA1 and KPNA2. 

Subcellular Location:
Nucleus. 

Tissue Specificity:
Widely expressed with highest levels in skeletal muscle, placenta, heart, spleen, testis and thyroid. 

Database links:
UniProtKB/Swiss-Prot: Q8WYA6.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.