Anti-Caspase 5抗体与ICE有51%的同源性，并具有保守的活性中心QACRG。但caspase-5不能剪切pro-IL-1b ，在过量表达时可以诱导凋亡的发生。此抗体与caspase 4 同源。

产品编号 yb-6860R
英文名称 Anti-Caspase 5抗体
中文名称 半胱胺酸蛋白酶蛋白5抗体
别    名 Caspase-5 subunit p20; Apoptosis related cysteine protease; CASP 5; CASP5; Caspase-5; Caspase5; Caspase 5 apoptosis related cysteine peptidase; caspase 5 apoptosis related cysteine protease; ICE; ICE(rel) III; ICE(rel)III; ICEREL III; ICERELIII; ICH 3; ICH 3 protease; ICH3; ICH3 protease; MGC141966; TY; TY protease.
Anti-Caspase 5抗体   
说 明 书 0.1ml  0.2ml  
研究领域 细胞生物  免疫学  细胞凋亡  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 48kDa
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Caspase 5
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
Caspase 5 belongs to the Ced3/ICE family of cystein proteases and is an upstream Caspase with a long prodomain. It undergoes a cleavage upon activation, leading to p20 and p10 subunits which have high homology with several other Caspases over the equivalent coding sequences. 

Subunit:
Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10kDa (p10) subunits.

Tissue Specificity:
Expressed in barely detectable amounts in most tissues except brain, highest levels being found in lung, liver and skeletal muscle.

Similarity:
Belongs to the peptidase C14A family.
Contains 1 CARD domain.


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

caspase-5与ICE有51%的同源性，并具有保守的活性中心QACRG。但caspase-5不能剪切pro-IL-1b ，在过量表达时可以诱导凋亡的发生。此抗体与caspase 4 同源。